| Name | Image | Tier | Pool | Description | Flavor |
|---|
| Black Cloud |  | Boss | Purple | Gain [E] at the start of your turn. Whenever you end your turn in CalmStance, lose [E] next turn. | There is always sunshine above the black clouds. |
| Crystal Sphere |  | Boss | Purple | The first time you Scry each turn, gain [E]. | You can use it to predict the future. But should you do it? |
| Cursed Pentagram |  | Boss | | Gain [E] at the start of your turn. Obtain a Curse for every 5 future non-Curse cards added to your deck. | Don't mess with the force you don't understand... |
| Dead Battery |  | Boss | | Gain [E] at the start of your turn. You cannot play more than 1 Power card per turn. | Press F to pay respects. |
| Energized Die |  | Boss | | Gain [E] at the start of your turn. Whenever you climb a floor, Energized Die is rerolled to have the negative effect of 1 of 6 other energy relics: 1 - Cursed Key, 2 - Sozu, 3 - Ectoplasm, 4 - Runic Dome, 5 - Philosopher's Stone, 6 - Busted Crown. | Alea iacta est. |
| High Heels |  | Boss | Green | Gain [E] at the start of your turn. At the start of combat, shuffle 2Clumsy Curses into your draw pile. | Elegant, but not very comfortable for combat. |
| Huge House |  | Boss | | Gain [E] at the start of your turn. Upon pickup, lose 1 random potion. Lose 50 Gold. Lower your Max HP by 5. Obtain 1Strike.Transform1 random card. | Is it adequate enough? |
| Magnifying Glass |  | Boss | | Gain [E] at the start of your turn. Enemies have 20% more HP. | The bigger they are, the harder they fall. |
| Never-Ending Sparkler |  | Boss | | Gain [E] at the start of your turn. 50% of Normal and Elite rooms are BurningRooms. | It sparks joy. |
| Ogre Head |  | Boss | | Gain [E] at the start of your turn. Whenever you play a card that targets an enemy, you have 50% chance to target another enemy. | Me smash you! Wait... who? |
| Old TV |  | Boss | Blue | Gain [E] at the start of your turn. At the start of combat, shuffle 1ReceptionProblems into your draw pile. | Too old to use, too good to throw away. |
| Pogo Stick |  | Boss | Green | Gain [E] at the start of your turn. Whenever you end a turn without discarding a card, take 4 damage. | Boing, boing, boing... |
| Red Rose |  | Boss | | Gain [E] at the start of your turn. ALL enemies start combat with 1Thorns. | There is no rose without a thorn. |
| Rotting Skull |  | Boss | Red | If your HP is at or below 50%, gain [E] and draw 1 additional card at the start of your turn. | Find the other one too! Is this the beginning of a new collection? |
| Spider Web |  | Boss | | Gain [E] at the start of your turn. Every 6 turns, add 1CaughtintheWeb into your hand. | Use it to catch your enemies, not to catch yourself... |
| Sticky Hand |  | Boss | | Gain [E] at the start of your turn. Whenever you would take a card in a future card reward, you take ALL the offered cards instead. | Definitely going to come in handy. |
| Tabasco Sauce |  | Boss | Red | Gain [E] at the start of your turn. Healing effects are reduced by 50%. | Ah, that's hot! That is hot! |
| Unstable Molecules |  | Boss | Blue | Gain [E] at the start of your turn. When a Frost orb triggers its passive ability 3 times, it is removed. | Maybe they should just visit a psychiatrist. |
